Determinants of Inter-Individual Variability in Corticomotor Excitability Induced by Paired Associative Stimulation.

ABSTRACT: Transcranial magnetic stimulation (TMS) is a well-established tool in probing cortical plasticity in vivo. Changes in corticomotor excitability can be induced using paired associative stimulation (PAS) protocol, in which TMS over the primary motor cortex is conditioned with an electrical peripheral nerve stimulation of the contralateral hand. PAS with an inter-stimulus interval of 25 ms induces long-term potentiation (LTP)-like effects in cortical excitability. However, the response to a PAS protocol tends to vary substantially across individuals. In this study, we used univariate and multivariate data-driven methods to investigate various previously proposed determinants of inter-individual variability in PAS efficacy, such as demographic, cognitive, clinical, neurophysiological, a

SUBMITTER: Minkova L 

PROVIDER: S-EPMC6702284 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature