MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.

ABSTRACT: MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-κB and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions. Because of its role in lymphocyte activation and proliferation, inhibition of MALT1 proteolytic activity is of high interest for therapeutic targeting in autoimmunity and certain lymphomas. However, recent studies showing that Malt1 protease-dead knock-in (Malt1-PD) mice suffer from autoimmune disease have somewhat tempered the initial enthusiasm. Although it has been proposed that an imbalance between immune suppressive regulatory T cells (Tregs) and activated effector CD4⁺ T cells plays a key role in the autoimmune phenotype of Malt1-PD m

SUBMITTER: Demeyer A 

PROVIDER: S-EPMC6702287 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature