Serious Cardiovascular Adverse Events Reported with Intravenous Sedatives: A Retrospective Analysis of the MedWatch Adverse Event Reporting System.

ABSTRACT:

Background

Serious cardiovascular adverse events (SCAEs) associated with intravenous sedatives remain poorly characterized.

Objective

The objective of this study was to compare SCAE incidence, types, and mortality between intravenous benzodiazepines (i.e., diazepam, lorazepam, and midazolam), dexmedetomidine, and propofol in the USA over 8 years regardless of the clinical setting where it was administered.

Methods

The Food and Drug Administration's MedWatch Adverse Event Reporting System was searched between 2004 and 2011 using the Evidex^® platform from Advera Health Analytics, Inc. to identify all reports that included one or more of ten different SCAEs (package insert incidence ≥ 1%) and where an intravenous benzodiazepine, dexmedetomidine, or propofol wa

SUBMITTER: Duprey MS 

PROVIDER: S-EPMC6702539 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature