A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A_1c With Implications for Glycemic Status in U.S. Hispanics/Latinos.

ABSTRACT:

Objective

We aimed to identify hemoglobin A_1c (HbA_1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA_1c in U.S. Hispanics/Latinos with diverse genetic ancestries.

Research design and methods

We conducted a genome-wide association study (GWAS) of HbA_1c in 9,636 U.S. Hispanics/Latinos without diabetes from the Hispanic Community Health Study/Study of Latinos, followed by a replication among 4,729 U.S. Hispanics/Latinos from three independent studies.

Results

Our GWAS and replication analyses showed 10 previously known and novel loci associated with HbA_1c at genome-wide significance levels (P < 5.0 × 10^-8). In particular, two African ancestry-specific

SUBMITTER: Moon JY 

PROVIDER: S-EPMC6702612 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature