Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.

ABSTRACT: Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local concentrations and affect insulin secretion. GHSR has high constitutive activity and may act independently of ghrelin. The objective in this study was to determine whether an intraislet ghrelin-GHSR axis modulates insulin secretion and glucose metabolism using mouse models lacking ghrelin (Ghrl^-/- ) or GHSR (Ghsr^-/- ). Ghsr^-/- and Ghsr^+/+ mice had comparable islet ghrelin concentrations. Exogenous ghrelin

SUBMITTER: Gray SM 

PROVIDER: S-EPMC6702634 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature