Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli.

ABSTRACT:

Motivation

The effort to build a whole-cell model requires the development of new modeling approaches, and in particular, the integration of models for different types of processes, each of which may be best described using different representation. Flux-balance analysis (FBA) has been useful for large-scale analysis of metabolic networks, and methods have been developed to incorporate transcriptional regulation (regulatory FBA, or rFBA). Of current interest is the integration of these approaches with detailed models based on ordinary differential equations (ODEs).

Results

We developed an approach to modeling the dynamic behavior of metabolic, regulatory and signaling networks by combining FBA with regulatory Boolean logic, and ordinary differential equations. We use this ap

SUBMITTER: Covert MW 

PROVIDER: S-EPMC6702764 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature