Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy.

ABSTRACT:

Purpose

To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes.

Methods

Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made.

Results

Macular GCL was reduced in patients compared to controls (<

SUBMITTER: Garcia-Martin E 

PROVIDER: S-EPMC6702840 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature