¹⁹F Hyperpolarization of ¹⁵N-3-¹⁹F-Pyridine Via Signal Amplification by Reversible Exchange.

ABSTRACT: We report synthesis of ¹⁵N-3-¹⁹F-pyridine via Zincke salt formation with the overall 35% yield and 84% ¹⁵N isotopic purity. Hyperpolarization studies of Signal Amplification by Reversible Exchange (SABRE) and SABRE in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) were performed to investigate the mechanism of polarization transfer from parahydrogen-derived hydride protons to ¹⁹F nucleus in milli-Tesla and micro-Tesla magnetic field regimes in ¹⁵N-3-¹⁹F-pyridine and ¹⁴N-3-¹⁹F-pyridine. We found the mismatch between ¹⁵N and ¹⁹F magnetic field hyperpolarization profiles in the micro-Tesla regime indicating that the spontaneous hyperpolarization process likely happen

SUBMITTER: Chukanov NV 

PROVIDER: S-EPMC6703844 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature