Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal.

ABSTRACT: Constantly surrounded by kin or alien organisms in nature, eukaryotes and prokaryotes developed various communication systems to coordinate adaptive multi-entity behavior. In complex and overcrowded environments, they require to discriminate relevant signals in a myriad of pheromones to execute appropriate responses. In the human gut commensal Streptococcus salivarius, the cytoplasmic Rgg/RNPP regulator ComR couples competence to bacteriocin-mediated predation. Here, we describe a paralogous sensor duo, ScuR and SarF, which circumvents ComR in order to disconnect these two physiological processes. We highlighted the recurring role of Rgg/RNPP in the production of antimicrobials and designed a robust genetic screen to unveil potent/optimized peptide pheromones. Further mutational and

SUBMITTER: Mignolet J 

PROVIDER: S-EPMC6703854 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature