Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow.

ABSTRACT: Aging results in increased myelopoiesis, which is linked to the increased incidence of myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibit immune regulatory function and sequester in bone marrow (BM). PC number was increased in old BM, and they exhibited high expression of genes encoding inflammatory cytokines and pathogen sensors. Antibody-mediated depletion of PCs from old mice reduced the number of myeloid-biased hematopoietic stem cells and mature myeloid cells to levels in young animals, but lymphopoiesis was not rejuvenated, indicating that redundant mechanisms inhibit that process. PCs also regulated the production of inflammatory factors from BM stroma

SUBMITTER: Pioli PD 

PROVIDER: S-EPMC6703913 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature