Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury.

ABSTRACT: A key event in the pathophysiology of traumatic brain injury (TBI) is the influx of substantial amounts of Ca²⁺ into neurons, particularly in the thalamus. Detection of this calcium influx in vivo would provide a window into the biochemical mechanisms of TBI with potentially significant clinical implications. In the present work, our central hypothesis was that the Ca²⁺ influx could be imaged in vivo with the relatively recent MRI technique of quantitative susceptibility mapping (QSM). Wistar rats were divided into five groups: naive controls, sham-operated experimental controls, single mild TBI, repeated mild TBI, and single severe TBI. We employed the lateral fluid percussion injury (FPI) model, which replicates clinical TBI without skull fracture, performed 9.4 Tes

SUBMITTER: Schweser F 

PROVIDER: S-EPMC6703923 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature