The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia.

ABSTRACT:

Objectives

Autoantibody testing is helpful for predicting the risk of progression to clinical arthritis in subjects at risk. Previous longitudinal studies have mainly selected autoantibody-positive arthralgia patients, and consequently the predictive values of autoantibodies were evaluated relative to one another. This study assessed the risks for arthritis development of ACPA, RF and/or anti-carbamylated protein antibodies (anti-CarP) in arthralgia patients considered at risk for RA by rheumatologists, based on clinical characteristics (clinically suspect arthralgia, CSA).

Methods

The baseline ACPA, RF and anti-CarP autoantibody status of 241 patients, consecutively included in the CSA cohort, was studied for risk of developing clinical arthritis during a median follow-up o

SUBMITTER: Ten Brinck RM 

PROVIDER: S-EPMC6703997 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature