Association between p62 expression and clinicopathological characteristics in oral leukoplakia.

ABSTRACT:

Objective

Oral leukoplakia is keratinized lesions in the buccal mucosa, tongue, and gingiva. It is the most common oral precancerous lesion; oxidative stresses and irrelevant autophagy have been reported to be the cause of oncogenesis. p62, a cytoplasmic protein induced by oxidative stress, is an adaptor protein involved in the formation of protein aggregates and induction and inhibition of autophagy. The inhibition of autophagy induces p62 overexpression and promotes oncogenesis via the oncogenic signaling pathway. The aim of the present study was to elucidate the involvement of intracellular expression of p62 in oral leukoplakia and to address its potential clinical implementation as a biomarker to predict malignant transformation.

Material and methods

Fifty samples from s

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC6704027 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature