A sustainable approach for the extraction of cholesterol-lowering compounds from an olive by-product based on CO₂-expanded ethyl acetate.

ABSTRACT: Olive (Olea europaea) processing results in large amounts of by-products that contain valuable molecules such as phenolic compounds and phytosterols. These molecules have demonstrated to reduce blood cholesterol levels. This work proposes the development of a method to obtain simultaneously phenolic compounds and phytosterols from the olive stone using CO₂-expanded liquid extraction. Hansen solubility parameters were employed for the theoretical prediction of the most suitable bio-based solvent to extract target compounds. The Box-Behnken experimental design was employed to select the optimal conditions of pressure (8-25 MPa), the molar fraction of CO₂ in ethyl acetate (0.15-0.55), and the temperature (40-80 °C). Extracts showing the highest and the lowest reductions

SUBMITTER: Vasquez-Villanueva R 

PROVIDER: S-EPMC6704084 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature