Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

ABSTRACT: Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI), frequently occur together. Clinical observation has long held that TBI can accelerate fracture healing, yet the complexity and heterogeneity of these injuries has produced conflicting data with limited information on underlying mechanisms. We developed a murine polytrauma model with TBI and fracture to evaluate healing in a controlled system. Fractures were created both contralateral and ipsilateral to the TBI to test whether differential responses of humoral and/or neuronal systems drove altered healing patterns. Our results show increased bone formation after TBI when injuries occur contralateral to each other, rather than ipsilateral, suggesting a role of the nervous system based on the crossed neu

SUBMITTER: Morioka K 

PROVIDER: S-EPMC6704103 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature