Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.

ABSTRACT: Extensive biomarker discoveries for DMD have occurred in the past 7 years, and a vast array of these biomarkers were confirmed in independent cohorts and across different laboratories. In these previous studies, glucocorticoids and age were two major confounding variables. In this new study, using SomaScan technology and focusing on a subset of young DMD patients who were not yet treated with glucocorticoids, we identified 108 elevated and 70 decreased proteins in DMD relative to age matched healthy controls (p value < 0.05 after adjusting for multiple testing). The majority of the elevated proteins were muscle centric followed by cell adhesion, extracellular matrix proteins and a few pro-inflammatory proteins. The majority of decreased proteins were of cell adhesion, however, some had to

SUBMITTER: Hathout Y 

PROVIDER: S-EPMC6704115 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature