Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults.

ABSTRACT: Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP) index, a dynamic secretory molecular pattern indicative of cellular senescence. We also tested the potential moderators of the association between major depression and the SASP index. We included 1165 young and middle-aged adults (527 with a current major depressive episode (cMDE) and 638 with no lifetime history of depression) from a community-based cohort from the Netherlands. We calculated the SASP index based on a previously developed composite index involving 19 biomarkers. cMDE had higher SASP index values (t₍₁₁₆₃₎ = 2.93, p = 0.003) co

SUBMITTER: Diniz BS 

PROVIDER: S-EPMC6704136 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature