Ontology highlight
ABSTRACT:
SUBMITTER: Patel AM
PROVIDER: S-EPMC6704264 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Translational psychiatry 20190821 1
Duchenne muscular dystrophy (DMD) results, beside muscle degeneration in cognitive defects. As neuronal function is supported by astrocytes, which express dystrophin, we hypothesized that loss of dystrophin from DMD astrocytes might contribute to these cognitive defects. We generated cortical neuronal and astrocytic progeny from induced pluripotent stem cells (PSC) from six DMD subjects carrying different mutations and several unaffected PSC lines. DMD astrocytes displayed cytoskeletal abnormali ...[more]