Expression of ventral telencephalon transcription factors ASCL1 and DLX2 in the early fetal human cerebral cortex.

ABSTRACT: In rodent ventral telencephalon, diffusible morphogens induce expression of the proneural transcription factor ASCL1, which in turn induces expression of the transcription factor DLX2 that controls differentiation of cortical interneuron precursors and their tangential migration to the cerebral cortex. RNAseq analysis of human fetal samples of dorsal telencephalon revealed consistently high cortical expression of ASCL1 and increasing expression of DLX2 between 7.5 and 17 post-conceptional weeks (PCW). We explored whether cortical expression of these genes represented a population of intracortically derived interneuron precursors. Immunohistochemistry revealed an ASCL1⁺ /DLX2⁺ population of progenitor cells in the human ganglionic eminences between 6.5 and 12 PCW, but

SUBMITTER: Alzu'bi A 

PROVIDER: S-EPMC6704271 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature