Differential neural reward mechanisms in treatment-responsive and treatment-resistant schizophrenia.

ABSTRACT:

Background

The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing, but these have not directly compared groups of treatment-refractory and non-refractory patients.

Methods

In the current functional magnetic resonance imaging study, 21 patients with treatment-resistant schizophrenia (TRS), 21 patients with non-treatment-resistant schizophrenia (NTR), and 24 healthy controls (HC) performed a probabilistic reinforcement learning task, utilizing emotionally valenced face stimuli which elicit a social bias toward happy faces. Beh

SUBMITTER: Vanes LD 

PROVIDER: S-EPMC6704377 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature