Role of intracellular Ca²⁺-based mechanotransduction of human periodontal ligament fibroblasts.

ABSTRACT: Human periodontal ligament (hPDL) fibroblasts are thought to receive mechanical stress (MS) produced by orthodontic tooth movement, thereby regulating alveolar bone remodeling. However, the role of intracellular calcium ([Ca²⁺]_i)-based mechanotransduction is not fully understood. We explored the MS-induced [Ca²⁺]_i responses both in isolated hPDL fibroblasts and in intact hPDL tissue and investigated its possible role in alveolar bone remodeling. hPDL fibroblasts were obtained from healthy donors' premolars that had been extracted for orthodontic reasons. The oscillatory [Ca²⁺]_i activity induced by static compressive force was measured by a live-cell Ca²⁺ imaging system and evaluated by several feature extraction m

SUBMITTER: Ei Hsu Hlaing E 

PROVIDER: S-EPMC6704454 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature