Inflammatory Mediators in Xanthelasma Palpebrarum: Histopathologic and Immunohistochemical Study.

ABSTRACT:

Purpose

To evaluate the expression of inflammatory mediators in xanthelasma palpebrarum.

Methods

In this retrospective histopathologic case-control study, xanthelasma specimens obtained from the private practice and pathology archives of 1 author (R.Z.S.) were analyzed and compared with the blepharoplasty tissues from age- and sex-matched controls. Paraffin-embedded tissue sections were stained with hematoxylin-eosin and CD3, CD20, CD163, cyclooxygenase-1, inducible nitric oxide synthase, matrix metallopeptidase-9, and myeloperoxidase antibodies. Immunostaining was quantified by light microscopy and with a computerized image analysis system of scanned images.

Results

Hematoxylin-eosin-stained preparations of xanthelasma specimens demonstrated significantly more intens

SUBMITTER: Govorkova MS 

PROVIDER: S-EPMC6704479 | biostudies-literature | 2018 May/Jun

REPOSITORIES: biostudies-literature