Remodeling of substrate consumption in the murine sTAC model of heart failure.

ABSTRACT:

Background

Energy metabolism and substrate selection are key aspects of correct myocardial mechanical function. Myocardial preference for oxidizable substrates changes in both hypertrophy and in overt failure. Previous work has shown that glucose oxidation is upregulated in overpressure hypertrophy, but its fate in overt failure is less clear. Anaplerotic flux of pyruvate into the tricarboxylic acid cycle (TCA) has been posited as a secondary fate of glycolysis, aside from pyruvate oxidation or lactate production.

Methods and results

A model of heart failure that emulates both valvular and hypertensive heart disease, the severe transaortic constriction (sTAC) mouse, was assayed for changes in substrate preference using metabolomic and carbon-13 flux measurements. Quantitativ

SUBMITTER: Turer A 

PROVIDER: S-EPMC6704481 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature