Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.

ABSTRACT:

Background

Breast cancer is a life-threatening disease in females and the leading cause of mortality among the female population, presenting huge challenges for prognosis and treatment. ITM2A is a member of the BRICHOS superfamily, which are thought to have a chaperone function. ITM2A has been identified to related to ovarian cancer progress recently. However, the biological role of ITM2A in breast cancer remains largely unclear.

Methods

Quantitative real-time polymerase chain reaction (qRT-PCR), western blotting assay and immunohistochemistry staining were used to analyzed the expression level of ITM2A. The patient overall survival versus ITM2A expression level was evaluated by Kaplan-Meier analysis. MTT assay, EdU incorporation assay and colony formation assay were used to

SUBMITTER: Zhou C 

PROVIDER: S-EPMC6704577 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature