Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation.

ABSTRACT:

Background

Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation. However, the role of parkin in ethanol-induced liver disease has not been reported. Here, we tested the effect of parkin on ethanol-induced fatty liver in parkin knockout (KO) mice with chronic ethanol feeding.

Methods

Male wild type (WT) and parkin KO mice (10-12 weeks old, n = 10) were fed on a Lieber-DeCarli diet containing 6.6% ethanol for 10 days. Liver histological, biochemical, and gene-expression studies were performed.

Results

Parkin KO mice exhibited lower hepatosteatosis after ethanol consumption. Because several studies reported that β-ca

SUBMITTER: Lee DH 

PROVIDER: S-EPMC6704582 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature