Ratiometric Cu²⁺ Binding, Cell Imaging, Mitochondrial Targeting, and Anticancer Activity with Nanomolar IC₅₀ by Spiro-Indoline-Conjugated Calix[4]arene.

ABSTRACT: A triazole-derivatized, spiro-indoline-linked, 1,3-di-derivative of calix[4]arene (L) has been synthesized to take advantage of its ion-binding capability in the ring-open form. Indeed, the spiro-indoline moiety is well known for its photochromic, acidochromic, and metallochromic properties. Therefore, the L has been explored for Cu²⁺ binding, cell imaging, and anticancer activity of the corresponding complex since Cu²⁺ complexes are known for such activity. The conversion from the closed to open form of L is expedited by light or proton, while the metal ion can open as well as stabilize it. The open form of L showed binding of Cu²⁺ ratiometrically as demonstrated by absorption and fluorescence spectroscopy. This leads to the for

SUBMITTER: Nag R 

PROVIDER: S-EPMC6704586 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature