An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets.

ABSTRACT:

Background

Host immune response is coordinated by a variety of different specialized cell types that vary in time and location. While host immune response can be studied using conventional low-dimensional approaches, advances in transcriptomics analysis may provide a less biased view. Yet, leveraging transcriptomics data to identify immune cell subtypes presents challenges for extracting informative gene signatures hidden within a high dimensional transcriptomics space characterized by low sample numbers with noisy and missing values. To address these challenges, we explore using machine learning methods to select gene subsets and estimate gene coefficients simultaneously.

Results

Elastic-net logistic regression, a type of machine learning, was used to construct separate cla

SUBMITTER: Torang A 

PROVIDER: S-EPMC6704630 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature