Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens.

ABSTRACT:

Background

Poultry breeding programs have been focused on improvement of growth and carcass traits, however, this has resulted in correlated changes in internal organ weights and increased incidence of metabolic disorders. These disorders can affect feed efficiency or even cause death. We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. We integrated knowledge of haplotype blocks, selection signature regions and sequencing data to refine the list of PCGs.

Results

Estimated genomic heritability for internal organ traits in chickens ranged from low (LUNGWT, 0.06) to hig

SUBMITTER: Moreira GCM 

PROVIDER: S-EPMC6704653 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature