Genotypes of glycoprotein B gene among the Indian symptomatic neonates with congenital CMV infection.

ABSTRACT:

Background

Cytomegalovirus [CMV] is a causative agent of congenital infection worldwide and often leads to neurological deficits and hearing loss in newborns. Infants born with symptomatic congenital Cytomegalovirus infection [cCMV] are at significant high risk for developing adverse long-term outcomes. In this study, we look into the sequence variability of surface glycoprotein B [gB] encoding region in newborns with symptomatic CMV infection for the first time in Eastern region of India.

Methods

576 suspected newborns from seropositive mothers were subjected to the study and ELISA was used to confirm CMV infection. Different genotypes and their subtypes were determined using multiplex nested-PCR. Viral load of different glycoprotein B [gB] genotypes was measured using RT-P

SUBMITTER: Sarkar A 

PROVIDER: S-EPMC6704666 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature