Measuring similarity between gene interaction profiles.

ABSTRACT:

Background

Gene and protein interaction data are often represented as interaction networks, where nodes stand for genes or gene products and each edge stands for a relationship between a pair of gene nodes. Commonly, that relationship within a pair is specified by high similarity between profiles (vectors) of experimentally defined interactions of each of the two genes with all other genes in the genome; only gene pairs that interact with similar sets of genes are linked by an edge in the network. The tight groups of genes/gene products that work together in a cell can be discovered by the analysis of those complex networks.

Results

We show that the choice of the similarity measure between pairs of gene vectors impacts the properties of networks and of gene modules detected

SUBMITTER: Barido-Sottani J 

PROVIDER: S-EPMC6704681 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature