Dataset Information

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47^phox phosphorylation, NADPH oxidase activation and MuRF1 expression.

ABSTRACT:

Background

Spaceflight or microgravity conditions cause myocardial atrophy and dysfunction, contributing to post-flight orthostatic intolerance. However, the underlying mechanisms remain incompletely understood and preventive approaches are limited. This study investigated whether and how losartan, a blocker of angiotensin-II receptor, preserved cardiomyocyte size and prevented myocardial dysfunction during microgravity.

Method

Adult male mice were suspended with their tails to simulate microgravity. Echocardiography was performed to assess myocardial function. Heart weight and cardiomyocyte size were measured. NADPH oxidase activation was determined by analyzing membrane translocation of its cytosolic subunits including p47^phox, p67^phox and Rac1. Heart

SUBMITTER: Liang L

PROVIDER: S-EPMC6704685 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Dataset Information

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47^phox phosphorylation, NADPH oxidase activation and MuRF1 expression.

Background

Method

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression.

Background

Method

OmicsDI is part of the ELIXIR infrastructure

Tweets

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47^phox phosphorylation, NADPH oxidase activation and MuRF1 expression.