Base excess and hematocrit predict response to indomethacin in very low birth weight infants with patent ductus arteriosus.

ABSTRACT:

Background

The treatment of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants remains a challenge. The ability to predict which infants will respond to indomethacin could spare some from the risks of unnecessary medications. Our objective was to determine if indicators of acid-base homeostasis could predict response to indomethacin treatment for ductal closure, and thus help guide treatment decisions.

Methods

We performed a retrospective analysis of medical records of VLBW (< 1500 g) neonates with hemodynamically significant PDA born at our institution between January 2009 and December 2012; all infants included in the study were treated with indomethacin for ductal closure within the first 2 weeks of life. We extracted data for a number of clinical vari

SUBMITTER: Mydam J 

PROVIDER: S-EPMC6704716 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature