Association Between Drug Treatments for Patients With Osteoporosis and Overall Mortality Rates: A Meta-analysis.

ABSTRACT:

Importance

Previous studies have reported that drug treatments, particularly treatment with bisphosphonates, is associated with reduced overall mortality rates in addition to decreased fracture risk. If so, drug treatments should be recommended for this reason alone, regardless of a patient's risk of fracture.

Objective

To assess whether randomized clinical trials demonstrate that treatment with bisphosphonates, particularly zoledronate, is associated with reduced mortality rates.

Data sources

Science Direct, MEDLINE, Embase, and the Cochrane Library were searched for randomized placebo-controlled clinical trials of drug treatments for osteoporosis published after 2009 and published or in press before April 19, 2019. Conference abstracts from annual osteoporosis socie

SUBMITTER: Cummings SR 

PROVIDER: S-EPMC6704731 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature