Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature.

ABSTRACT: Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder, bipolar disorder and schizophrenia may be associated with accelerated cellular aging, indicated by shortened leukocyte telomere length (LTL), which could underlie this connection. Telomere shortening occurs with repeated cell division and is reflective of a cell's mitotic history. It is also influenced by cumulative exposure to inflammation and oxidative stress as well as the availability of telomerase, the telomere-lengthening enzyme. Precariously short telomeres can cause cells to undergo senescence, apoptosis or genomic inst

SUBMITTER: Muneer A 

PROVIDER: S-EPMC6705109 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature