Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.

ABSTRACT: Doxorubicin (DOX) is widely used as a first-line chemotherapeutic drug for various malignancies. However, DOX causes severe cardiotoxicity, which limits its clinical uses. Oxidative stress is one of major contributors to DOX-induced cardiotoxicity. While autophagic flux serves as an important defense mechanism against oxidative stress in cardiomyocytes, recent studies have demonstrated that DOX induces the blockage of autophagic flux, which contributes to DOX cardiotoxicity. The present study investigated whether nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD)⁺, prevents DOX cardiotoxicity by improving autophagic flux. We report that administration of NR elevated NAD⁺ levels, and reduced cardiac injury and myocardial dysfunction in D

SUBMITTER: Zheng D 

PROVIDER: S-EPMC6705112 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature