Effect of Bisphosphonates on Fracture Outcomes Among Frail Older Adults.

ABSTRACT:

Background

Bisphosphonates are seldom used in frail, older adults, in part due to lack of direct evidence of efficacy in this population and increasing concerns about safety.

Objective

We estimated the effects of bisphosphonates on hip fractures, nonvertebral fractures, and severe esophagitis among frail, older adults.

Design

Population-based retrospective cohort using 2008 to 2013 linked national Minimum Data Set assessments; Online Survey Certification and Reporting System records; and Medicare claims.

Setting

US nursing homes (NHs).

Participants

Long-stay NH residents 65 years and older without recent osteoporosis medication use (N = 24,571). Bisphosphonate initiators were 1:1 propensity score matched to calcitonin initiators (active comparator).

M

SUBMITTER: Zullo AR 

PROVIDER: S-EPMC6705123 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature