Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population.

ABSTRACT:

Background & aims

The potential interaction between family history of liver cancer and HBV infection on liver cancer has not been fully examined.

Methods

We conducted a population-based case-control study composed of 2011 liver cancer cases and 7933 controls in Jiangsu province, China from 2003 to 2010. Data on major risk or protective factors were collected and HBV/HCV sero-markers were assayed using blood samples. Semi-Bayes (SB) adjustments were applied to provide posterior estimates.

Results

Both family history of liver cancer (adjusted odds ratios [OR]: 4.32, 95% confidence intervals [CI]: 3.25-5.73) and hepatitis B surface antigen (HBsAg) positivity (adjusted OR: 9.94, 95% CI: 8.33-11.87) were strongly associated with liver cancer development. For individuals wi

SUBMITTER: Liu X 

PROVIDER: S-EPMC6705127 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature