Imprint of assortative mating on the human genome.

ABSTRACT: Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans^1-5 and has evolutionary consequences^6-8. Under Fisher's classical theory⁶, assortative mating is predicted to induce a signature in the genome at trait-associated loci that can be detected and quantified. Here, we develop and apply a method to quantify assortative mating on a specific trait by estimating the correlation (θ) between genetic predictors of the trait from single nucleotide polymorphisms on odd- versus even-numbered chromosomes. We show by theory and simulation that the effect of assortative mating can be quantified in the presence of population stratification. We applied this approach to 32 complex traits and diseases using single nucleotide

SUBMITTER: Yengo L 

PROVIDER: S-EPMC6705135 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature