Effect of Bismuth Subsalicylate vs Placebo on Use of Antibiotics Among Adult Outpatients With Diarrhea in Pakistan: A Randomized Clinical Trial.

ABSTRACT:

Importance

Many of the 4.5 billion annual episodes of diarrhea are treated unnecessarily with antibiotics; prevalence of antibiotic resistance among diarrheal pathogens is increasing. Knowledge-based antibiotic stewardship interventions typically yield little change in antibiotic use.

Objective

To compare antibiotic use among adult outpatients with diarrhea given bismuth subsalicylate (BSS) or placebo.

Design, setting, and participants

This randomized clinical trial took place from April to October 2014. Participants were patients aged 15 to 65 years with acute, nonbloody diarrhea from 22 outpatient clinics in Karachi, Pakistan. Participants were interviewed about symptoms and health care utilization during the 5 days after enrollment. Group assignment was concealed f

SUBMITTER: Bowen A 

PROVIDER: S-EPMC6705140 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature