An Immunological Stairway to Severe Tissue Complication Assembly in Bothrops atrox Snakebites.

ABSTRACT: Snakebites are a serious public health problem and, in the Amazon, the Bothrops atrox snake is the most frequent cause of envenomation. B. atrox venom (BaV) causes pathophysiological changes with intense, local inflammatory processes, such as severe tissue complication (STC). However, mechanisms associated with the inflammatory process in humans are still poorly understood. Thus, in this study, we sought to describe the profile of local and systemic immunological soluble molecules in Bothrops envenomation patients treated at a specialist tertiary healthcare unit in the Brazilian Amazon. An analytical and prospective study was performed with patients who had snakebites with different clinical outcomes (STC and Mild Tissue Complication-MTC) using venous blood and blister

SUBMITTER: Ibiapina HNS 

PROVIDER: S-EPMC6705225 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature