Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers.

ABSTRACT: Because of excellent bioavailability and high biocompatibility, solid lipid nanoparticles (SLNs) have gained attention in recent years, especially in drug delivery systems. SLNs are composed of a drug that is loaded in a lipid matrix and stabilized by surfactants. In this work, we have investigated the feasibility of the acoustic cavitation-assisted hot melt mixing method for the formulation of SLNs using different stabilizers. A lipid Compritol 888 ATO (CPT) and a poorly water-soluble drug ketoprofen (KP) were used as a model lipid and drug, respectively. Gelucire 50/13 (GEL), poloxamer 407 (POL), and Pluronic F-127 (PLU) were used as the stabilizers. The effect of the stabilizers on the physico-chemical properties of SLNs was thoroughly studied in this work. The particle size and stabili

SUBMITTER: Kumar R 

PROVIDER: S-EPMC6705237 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature