Metformin prescription status and abdominal aortic aneurysm disease progression in the U.S. veteran population.

ABSTRACT:

Background

Identification of a safe and effective medical therapy for abdominal aortic aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort studies indicate that metformin, the world's most commonly prescribed oral hypoglycemic agent, may limit AAA enlargement. We sought to validate these preliminary observations in a larger cohort.

Methods

All patients with asymptomatic AAA disease managed in the Veterans Affairs Health Care System between 2003 and 2013 were identified by International Classification of Diseases, Ninth Revision codes. Those with a concomitant diagnosis of diabetes mellitus who also received two or more abdominal imaging studies (computed tomography, magnetic resonance imaging, or ultrasound) documenting the presence and size

SUBMITTER: Itoga NK 

PROVIDER: S-EPMC6706071 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature