Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice.

ABSTRACT: Stimulant abuse is disproportionately common in HIV-positive persons. Both HIV and stimulants are independently associated with deficits in reward-based decision making, but their interactive and/or additive effects are poorly understood despite their prevalent co-morbidity. Here, we examined the effects of cocaine dependence and HIV infection in 69 adults who underwent functional magnetic resonance imaging while completing an economic loss aversion task. We identified two neural networks that correlated with the evaluation of the favorable characteristics of the gamble (i.e. higher gains/lower losses: ventromedial prefrontal cortex, anterior cingulate, anterior and posterior precuneus and visual cortex) versus unfavorable characteristics of the gamble (i.e. lower gains/higher losses: dors

SUBMITTER: Meade CS 

PROVIDER: S-EPMC6706251 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature