Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

ABSTRACT:

Background

The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective

Our objective was to better understand the mechanism, cross-reactivity, and scope of PEG hypersensitivity.

Methods

Two cases with a past history of immediate hypersensitivity to PEG-containing medications were used to study potential mechanisms and cross-reactivity of immediate reactions to PEG 3350. Skin testing and oral challenges with PEG and polysorbate-containing agents were employed to determine clinical reactivity and cross-reactivity between the 2 allergens. Enzyme-linked

SUBMITTER: Stone CA 

PROVIDER: S-EPMC6706272 | biostudies-literature | 2019 May - Jun

REPOSITORIES: biostudies-literature