Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury.

ABSTRACT: BACKGROUND AND AIMS:The aims were to review the diagnosis, testing and presentation of acute hepatitis C (HCV) in patients initially diagnosed to have drug-induced liver injury (DILI) enrolled in the US DILI Network. METHODS:All patients with suspected DILI underwent testing for competing causes of liver injury and returned for 6-month follow-up. Causality was adjudicated by consensus expert opinion. RESULTS:Between 2004 and 2016, 1518 patients were enrolled and adjudicated and underwent 6 months of follow-up. Initial locally acquired anti-HCV results were available in 1457 (96%), but HCV RNA in only 795 (52%). Stored sera were available for repeat testing, so that results were available on all 1518 patients (1457 for anti-HCV and 1482 for HCV RNA). A total of 104 subjects (6.9%) had evide

SUBMITTER: Ahmad J 

PROVIDER: S-EPMC6706305 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature