Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster.

ABSTRACT:

Background

Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As abnormal alterations in histone acetylation and methylation show a cause and effect relationship with AD, we investigated the role of several Jumonji domain-containing histone demethylase (JHDM) genes, which have yet to be studied in AD pathology.

Methods

To examine alterations of several JHDM genes in AD pathology, we performed bioinformatics analyses of JHDM gene expression profiles in brain tissue samples from deceased AD patients. Furthermore, to investigate the possible relationship between alterations in JHDM gene

SUBMITTER: Park SY 

PROVIDER: S-EPMC6706347 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature