Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.

ABSTRACT: Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated this in a double-blind, placebo-controlled, parallel-arm study. We investigated 33 antipsychotic-naïve subjects at clinical high risk for psychosis (CHR) randomised to 600 mg oral cannabidiol or placebo and compared them with 19 healthy controls. We used the monetary incentive delay task while participants underwent fMRI to study reward processing, known to be abnormal in psychosis. Reward and loss anticipation phases were combined to examine a motivational salience condition and compared with neutral condition. We observed abnormal activation in the left insula/parietal operculum in CHR pa

SUBMITTER: Wilson R 

PROVIDER: S-EPMC6706374 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature