Evaluation of the safety of using propofol for paediatric procedural sedation: A systematic review and meta-analysis.

ABSTRACT: Propofol is one of the most widely used drugs for paediatric procedural sedation owing to its known advantages, but some concerns remain regarding respiratory and/or cardiac complications in patients receiving propofol. Although a considerable number of randomised controlled clinical trials (RCTs) have been conducted to compare it with other sedative agents or opioids for children undergoing various procedures, propofol is still being used off-label for this indication in many countries. We performed a systematic review and meta-analysis of those RCTs to provide an overall summation of evidence that can potentially be considered for further regulatory decisions, including reimbursement policies. We searched for RCTs in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials

SUBMITTER: Kim S 

PROVIDER: S-EPMC6706375 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature