Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context.

ABSTRACT: The lymphatic vasculature mediates essential physiological functions including fluid homeostasis, lipid and hormone transport, and immune cell trafficking. Recent studies have suggested that promoting lymphangiogenesis enhances cardiac repair following injury, but it is unknown whether lymphangiogenesis is required for cardiac regeneration. Here, we describe the anatomical distribution, regulation, and function of the cardiac lymphatic network in a highly regenerative zebrafish model system using transgenic reporter lines and loss-of-function approaches. We show that zebrafish lacking functional vegfc and vegfd signaling are devoid of a cardiac lymphatic network and display cardiac hypertrophy in the absence of injury, suggesting a role for these vessels in cardiac tissue hom

SUBMITTER: Vivien CJ 

PROVIDER: S-EPMC6706389 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature