Linkage of CD8⁺ T cell exhaustion with high-fat diet-induced tumourigenesis.

ABSTRACT: Obesity increases the risk of cancer. Increased levels of hormones (such as oestrogen, insulin, insulin-like growth factor, and leptin), free fatty acid-induced production of reactive oxygen species, an altered intestinal microbiome and chronic inflammation are known to be associated with an increased cancer risk in obese subjects. However, the mechanism underlying the connection between obesity and cancer development remains elusive. Here, we show that a high-fat diet (HFD) promotes tumour initiation/progression and induces a phenotypic switch from PD-1^- CD8⁺ non-exhausted T cells to PD-1⁺ CD8⁺ exhausted T cells in a murine breast cancer model. While PD-1^- CD8⁺ non-exhausted T cells predominated in the mammary glands of nor

SUBMITTER: Kado T 

PROVIDER: S-EPMC6706391 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature